Adenoviral vectors will transduce a wide range of target cells resulting in high-level gene expression. They are non-integrating vectors so expression in dividing cells is progressively lost. First ...

Among these, lentivirus-based vectors, derived from the HIV-1 retrovirus, are of growing interest in gene and cell therapy, particularly in immuno-oncology, due to their ability to infect dividing ...

Since lentiviral vectors can transduce both dividing and nondividing cells, ... Up to 45% and 73% of dividing and nondividing cells, respectively, could be transduced with two lentiviral vectors.

Explore the latest advances in R&D and manufacturing of in vivo lentiviral vectors. Discover the challenges faced in this process and the innovative solutions being developed in the field.