Once inside the cells and after aquation, it leads to the formation of CDDP–DNA adducts that interfere with DNA replication and transcription. Nonetheless, similar to many other anticancer drugs, CDDP ...

Studying ancient DNA from the Maya region has always been challenging because the tropical climate makes it hard to preserve genetic material. Despite these difficulties, the research team achieved a ...

This enhancement was accompanied by the upregulation of essential components in the lytic phase of EBV DNA replication, including a viral oncogene BARF1 (Hoebe et al, 2013), the BCL-2-like antagonists ...

Trading into the 2026 draft, Pius Suter as a sensible free agency target and a juggernaut mentality: Leaflets Where draft picks play matters, at least a little Goalies for the Maple Leafs to keep an ...

The recent pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) highlighted a critical need to discover more effective antivirals. While therapeutics for SARS-CoV-2 exist, ...

One challenge with selecting AAV mutant libraries for variants that alter virus production is the loss of genotype-phenotype linkages, which can occur under transfection conditions that favor ...

Ensuring that DNA replication occurs at the right stage of the cell cycle is of crucial importance in biology. In bacteria, DNA replication begins with the assembly of a DNA-protein complex called the ...

Lincoln, RI (02865) Today. Sunny to partly cloudy. High near 85F. Winds WNW at 10 to 15 mph..

DNA replication is a fundamental process required of all cell types (1–3).Replicative polymerases (Pol), such as the leading-strand polymeraseε (Polε) and lagging-strand Polδ, synthesize DNA with ...

Ghost hunters. At the Xingyi archaeological site in central Yunnan, dozens of burials were discovered that dated from the Neolithic period (7000 to 2000 B.C.) to the Bronze Age (2000 to 770 B.C.).