Mitochondrial transcription elongation factor maintains the balance between transcription and replication of mitochondrial DNA offering insights into potential treatments for mitochondrial disease ...

Research on mitochondrial DNA (mtDNA) reveals that the mitochondrial transcription elongation factor (TEFM) is crucial for maintaining the balance between mtDNA transcription and replication.

During transcription, DNA supercoiling occurs when torsional stress is introduced by the unzipping of a portion of the helix into two strands, one of which will be transcribed.

Scientists successfully induced gene expression from a DNA and evolution through continuous replication extracellularly using cell-free materials alone for the first time. By adding the genes ...

By clarifying how the DNA sequence affects transcription accuracy, the study offers a new perspective on its fidelity, suggesting that errors are not in random locations but are instead influenced ...

Drs Ursula A. Matulonis and Joyce F. Liu discuss targeting DNA damage and repair and replication stress in endometrial cancer.

Their findings, which were published March 7 in Science, one of world’s leading scientific journals, not only reveal new details about how secondary DNA structures like G4s can impede DNA replication, ...

A cell protein previously believed only to provide a scaffolding for DNA has also been shown to directly influence DNA transcription into RNA – the first step of the process by which an organism ...

New imaging tools reveal how within an hour of infection, the virus begins to alter our chromosomes to kick-start its own replication.

Results. PTX enhanced the levels of HBV 3.5-kb mRNA, HBV DNA, HBeAg, and HBsAg both in vitro and in vivo.PTX also promoted the activity of the HBV core promoter and transcription factor AP-1.