The authors created a useful collection of Rep protein variants with changes that alter the amino acid sequence, but these did not lead to clear improvements in how the virus worked. Instead, their ...

Notably, the recombination of these genes still allowed for DL DNA formation. As such, the genes must interfere with the plus-strand primer translocation or the circulation step. Inserting the foreign ...

The transcript slippage is essential for initiation complex stability and its ability to translocate the mitochondrial DNA polymerase gamma, PolG, which pre‐binds to OriL, downstream of the ...

Consumer DNA test kits, such as those offered by Ancestry.com, 23andMe and others, create huge privacy risks that most Americans may not be aware of. This is according to a "60 Minutes" report ...

In this process, regions downstream the RNA primer are removed resulting in RNA-to-DNA transition sites being separated from the ligation point of the H strand at the end of replication.

During S-phase, DNA replication takes place in five stages. They are: initiation, unwinding, primer synthesis, elongation, and termination. Helicase enzymes “unwind” the DNA double helix ...

DNA replication occurs in several steps that involve ... all RNA primers from the original strands. The gaps where the primer(s) had been are then filled by yet more complementary nucleotides.

Replication occurs when an enzyme called helicase unwinds and unzips the double helix into two single strands. A second enzyme called primase attaches a 'primer' to each of these unravelled strands, ...

After placement of primer in the exonuclease active site ... An important therapeutic approach to inhibit DNA replication is to commandeer the high catalytic efficiency of the chromosomal DNA ...