Tiny tweaks in DNA folding can have big effects. A study from Umeå University shows that even the most subtle changes in DNA's shape have an important influence on gene activity and energy production.

A University of Alberta research team has uncovered a new role for a genetic mutation previously known to be linked to ...

New research found that gene therapy for children with a form of severe combined immunodeficiency was successful in 95% of ...

In human cells, there are about 20,000 genes on a two-meter DNA strand—finely coiled up in a nucleus about 10 micrometers in diameter. By comparison, this corresponds to a 40-kilometer thread packed ...

RNA molecules carry instructions from DNA for making proteins that carry out much of the work of living cells. Knowing where these molecules are located in complex tissues is a critical part of ...

For stem cells to differentiate into the appropriate cell-type, transcription factors (TFs) must be tailored to highly specific expression patterns of lineage-specific genes. Abnormalities in the ...

The herpesvirus can manipulate our DNA with far more precision than previously thought. The virus condenses and changes the shape of our genetic material to hijack the host genes needed for ...

New findings highlight Telomir-1’s impact on CASP8 and GSTP1, two critical genes that regulate cell death and glutathione-based detoxification pathways often disrupted in cancer. MIAMI, FLORIDA / ...

Transcriptomic Predictors of Survival for Palbociclib + Endocrine Therapy Versus Capecitabine in Aromatase Inhibitor–Resistant Breast Cancer From the GEICAM/2013-02 PEARL Trial Our findings revealed a ...

Pathogenic variants in mitochondrial DNA (mtDNA) are a common cause of severe, often fatal, inherited metabolic disease. A reproductive care pathway was implemented to provide women carrying ...