The T lymphocyte compartment was distinctly altered among critical COVID-19 patients, with expanded effector memory cell subsets and elevated expression of cytotoxic and activation functional type ...

The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their ...

Under high NaCl circumstances, cytotoxic memory T cells increased the nuclear factor of activated T cell 5 (NFAT5) expression, resulting in prolonged survival in pancreatic cancer patients.

A paper published in Cell highlights how researchers have leveraged AI-based computational protein design to create a novel ...

TCEs promote the crosslinking of T cells with tumor cells by simultaneously binding to CD3 on T cells and BCMA on MM cells. This triggers the activation of T cells, releasing cytotoxic factors to ...

Ischemic stroke triggers an inflammatory response in the brain that is cytotoxic. In response to ischemic stroke, T-cells from mobilize to the brain and modulate both cytotoxic and protective ...

CCL5 bound to the CCR5 receptor on the surface of cytotoxic T cells, which further mediated T cell infiltration and ultimately regressed tumors.

We have developed a non-radioactive flow-cytometry assay to monitor and quantify the target-cell killing activities mediated by cytotoxic T lymphocytes (CTLs). This flow-cytometry CTL (FCC) assay ...

In this study, we report identification of an immunodominant cytotoxic T lymphocyte epitope of hAAT restricted by H2-D b in C57BL/6 mice that allows us to further characterize the adaptive immune ...

Treating cultured T cells with the engineered proteins did not have a detrimental effect on T cell function, but induced LCK enzyme activity. From the collection of engineered proteins, the ...

Participants were 324 consecutive CHL patients, comprising 132 patients with nodular sclerosis (NS), 35 patients with NS grade 2 (NS2), and 157 patients with mixed cellularity (MC). We evaluated the ...