Yet it remains challenging to measure the amplitudes and time scales of protein motions. Here we show that the cytolysin A (ClyA) nanopore was used as a molecular tweezer to trap a single ...

These bacteria can metabolize nutrients and complex carbohydrates. They also make cholesterol-dependent cytolysin-like (CDCL) toxins, which can poke holes in other microbes, causing them to die. But ...

Led by microbiology professor Rodney Tweten, the team studied Bacteroides bacteria, which produce cholesterol-dependent cytolysin-like (CDCL) toxins. These proteins help bacteria compete in the ...

The bacteria are also fierce protectors of their own turf. They produce proteins called cholesterol-dependent cytolysin-like (CDCL) toxins that punch holes in rival bacteria, causing them to burst ...

The bacteria are also fierce protectors of their own turf. They produce proteins called cholesterol-dependent cytolysin-like (CDCL) toxins that punch holes in rival bacteria, causing them to burst and ...

faecalis strains into low (<40%), intermediate (40-60%) and high (>60%) mortality groups. In addition to the cytolysin operon that produces toxins harmful to host cells, the genomic analysis yielded a ...

The bacteria are also fierce protectors of their own turf. They produce proteins called cholesterol-dependent cytolysin-like (CDCL) toxins that punch holes in rival bacteria. Tweten is studying CDCLs ...

Patients with alcoholic hepatitis “have a gut microbiome that is different in distribution,” Schooley said, often with increased numbers of Enterococcus faecalis that produce cytolysin ...

The drug candidate is developed by drug design technology in which a monoclonal antibody (anti-MTX5) is conjugated to cytolysin. It targets cells expressing fibroblast activation protein (FAP).

The drug candidate is developed by drug design technology in which a monoclonal antibody (anti-MTX5) is conjugated to cytolysin. It targets cells expressing fibroblast activation protein (FAP).

The approach also confirmed the presence of a virulence factor called cytolysin that can introduce hemolysis – where red blood cells break down and release their contents into the surrounding fluid.