2018; Turajlic et al., 2018). While the majority of driver gene alterations may be clonal, metastasis-specific driving genes have also been identified in some solid tumors (Brastianos et al., 2015; Hu ...

Panelists discuss how to approach second-line therapy decisions for patients with metastatic breast cancer, emphasizing the importance of biomarker testing, including ESR1 mutations, and considering ...

"On Friday, he was diagnosed with prostate cancer, characterized by a Gleason score of 9 (Grade Group 5) with metastasis to the bone." "While this represents a more aggressive form of the disease ...

Tumor-infiltrating clonal hematopoiesis increased the risk ... as a potential target for interventions that regulate tumor progression and metastasis in solid cancers." However, "many questions ...

Cancer metastasis—the spread of cancer to other organs—is the leading cause of death among cancer patients. Researchers have now uncovered a "genetic signature" of 177 genes shared across ...

A better understanding of prostate cancer metastasis opens possibilities for ... With barcoding, we were able to follow clonal cells as they spread to different metastatic sites throughout the ...

Characterizing clonal evolution in blood cancers like acute myeloid leukemia (AML) is critical for understanding their mutational histories and how cell populations change during disease development.

Study: Analysis of somatic mutations in whole blood from 200,618 individuals identifies pervasive positive selection and novel drivers of clonal hematopoiesis. Image Credit: BioFoto / Shutterstock ...

Overall, these findings contribute to our understanding of the clonal evolution of melanoma distant metastasis in matched tissues from individual patients—and these findings may have ...