On the “Messy with Christina Applegate & Jamie-Lynn Sigler” podcast, Applegate revealed the comment that inspired her to undergo surgery in her 20s.

Christina Applegate reunited with Ed O'Neill, who played her dad on "Married... with Children," on her "MeSsy" podcast.

It’s an unbreakable bond. Christina Applegate has a loving relationship with her 13-year-old daughter, Sadie Grace LeNoble, who she shares with her husband, Martyn LeNoble. The mother-daughter ...

Christina Applegate details painful MS relapse, hasn't slept for 24 hours or showered for 3 weeks Applegate discussed her symptoms on her podcast, "MeSsy," co-hosted by Jamie-Lynn Sigler.

On the “Messy with Christina Applegate & Jamie-Lynn Sigler” podcast, Applegate revealed the comment that inspired her to undergo surgery in her 20s.

Christina Applegate opened up about living with multiple sclerosis in a new interview and looked back at her warm reception at the Emmys.

Christina Applegate’s candor, humor and grit brought the audience to their feet in a standing ovation at the 75th Primetime Emmy Awards. They are qualities the “Dead to Me” star has shown ...

Christina Applegate, 52, and Jamie-Lynn Sigler, 42, open up to PEOPLE about how Applegate's multiple sclerosis diagnosis in 2021 “brought us together” ...

Christina Applegate is speaking candidly about her "really, really hard" battle with MS, describing it as the "worst thing I've ever had in my life." ...

Christina Applegate opens up about her very bad few weeks after she contracted COVID-19 for the very first time, and then it got worse with her getting sapovirus from ingesting someone else's ...

How Christina Applegate and Jamie-Lynn Sigler Are 'Helping Each Other Through' MS: 'We Both Needed This' (Exclusive) Christina Applegate, 52, and Jamie-Lynn Sigler, 42, open up to PEOPLE about how ...