Over the past two decades, the idea of targeting transcription factors to combat malignancies has turned into a clinical reality.

Pulmonary hypertension, despite advances in treatment, still has a poor prognosis, which is often associated with right heart failure, and for which pulmonary arterial hypertension (PAH) is a severe ...

SRF is a transcription factor directly controlling the expression of at least 200-300 genes, regulating cell growth, proliferation, apoptosis, and motility, and is indispensable for organ ...

For these targeted genes, the therapeutic agents exert antitumor effects by inhibiting cell proliferation, metastasis, and angiogenesis, reversing multidrug resistance, and inducing apoptosis.

SRF is a transcription factor directly controlling the expression of at least 200–300 genes, regulating cell growth, proliferation, apoptosis, and motility, and is indispensable for organ ...

The integration of cytokines into stem cell and organoid research has significantly advanced drug discovery by enabling more ...

In the present study, we investigated the functional link between miR-17-92 cluster and Wnt ... Finally, we found that low doses of LiCl promoted the proliferation of ICP2 and DF1 cells, while high ...

Deregulated apoptosis may also be the leading cause ... 11 and -12), which allow for interactions with other proteins, and link with signalling pathways. In another study, the sensitivity of NSCLC and ...

And the increased ratio could be a landmark of the early stage of apoptosis ... and SW1990 cells significantly inhibited tumor cell viability compared to Gemcitabine alone (Figure 7E). These results ...

These results indicate that blocking the proliferation and/or the apoptosis of synovial fibroblasts could help to control autoimmune joint inflammation. A real-time cell analysis system mainly based ...