Caspase-1 triggers programmed necrosis called pyroptosis by gasdermin-D (GSDMD) cleavage. GSDMD-deficient cells are, however, susceptible to caspase-1-mediated cell death. Researchers at Kanazawa ...

The activation of caspase-3 represents a critical step in the pathways leading to the biochemical and morphological changes that underlie apoptosis. Upon induction of apoptosis, the large (p17 ...

Caspase-1 triggers programmed necrosis called pyroptosis by gasdermin-D (GSDMD) cleavage. GSDMD-deficient cells are, however, susceptible to caspase-1-mediated cell death. Researchers at Kanazawa ...

The VIB researchers have also pointed out that this will require a great deal of 're-researching'. The previously supposed roles of caspase 12—with more than 9,000 citations—in cell death and ...

Caspase-1, -4, -5, and -12 mediate the immune response in humans. The inflammatory caspases are produced in the same way as proapoptotic caspases, as inactive procaspases in resting cells.

Study: Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and thrombosis.Image Credit: Kateryna Kon/ Shutterstock. This news article was a review of a ...

Caspase-2 was found to control SREBP1 and 2 activation by cleaving another protein called site-1 protease. "In NASH-free individuals, the activities of SREBP1 and SREBP2 are kept under control, ...

WALTHAM, Mass. & MONTREAL, March 06, 2025--Ventus Therapeutics, a clinical-stage biopharmaceutical company with two novel small-molecule programs entering Phase 2 development for immunological ...

Apoptosis is an important cellular process that allows cells to die in a programmed fashion, essential for embryo development, homeostasis, and cancer development.This 3D animation provides an ...

Scientists commonly use caspase assays to evaluate apoptosis, evaluating caspase activation—a hallmark of apoptosis initiation—with fluorescent dyes. Researchers often perform multiplex caspase assays ...

Caspase-3 reportedly unleashes tau fragments that form neurofibrillary tangles, and a recent report indicated that these fragments damaged synapses in people with progressive supranuclear palsy (see ...