Mammalian hosts coordinate various cell death pathways as part of the immune defense system against pathogens including ...

Apoptosis is dependent on caspase activation, whereas the caspase-independent necrotic signaling pathway remains largely uncharacterized. We show here that Fas kills activated primary T cells ...

Following neonatal H-I brain injury in mice (a model of cerebral palsy), there was evidence of apoptotic changes (neuronal caspase-3 activation), as well as accumulation of clusterin in dying neurons.

Luminescent gold nanoparticles (L-AuNPs) represent a novel class of luminescent nanomaterials that have attracted ...

Mammalian hosts coordinate various cell death pathways as part of the immune defense system against pathogens including Mycobacterium tuberculosis ...

Prof. MENG Guangxun's team from the Shanghai Institute of Immunity and Infection of the Chinese Academy of Sciences, and collaborators, have revealed a novel mechanism whereby a short form of IL-18, ...

The study also opens new avenues for treatment. Medications that inhibit IL-1β or caspase-1—the enzyme that activates IL-1β production—are promising candidates to prevent AF in at-risk patients, ...

Furthermore, they have demonstrated that it is possible to reprogram other cancer cells to become dependent on this enzyme – ...

A group of scientists in China has revealed a novel mechanism whereby a short form of IL-18, generated by caspase-3 cleavage in tumor cells, activates natural killer (NK) cells to suppress tumor ...

CBL-514, the world's first investigational drug for large-area localized fat reduction, has demonstrated significant efficacy in its second and the last Phase 2b study (CBL-0205) before Phase 3.54.2% ...