We report the discovery that cardiac glycosides, natural products in clinical use for the treatment of heart failure and atrial arrhythmia, are potent inhibitors of DNA double-strand break (DSB) ...

Vascular smooth muscle cells (SMCs), like all cells, acquire a cell-specific epigenetic signature during development that includes acquisition of a unique repertoire of histone and DNA modifications.

Smooth muscle cell migration occurs during vascular development, in response to vascular injury, and during atherogenesis. Many proximal signals and signal transduction pathways activated during ...

The membranes were blocked with Tris-buffered saline (TBS) containing 5% non-fat milk and incubated with the following primary antibodies at 4°C overnight: VEGFR-2 (ab39256; 1:1000; Abcam), ...

Circadian disruption, occurring in shift work, sleep deprivation, or dementia, increases the risk of sarcopenia, the age-related loss of muscle mass and strength. The cell-intrinsic and extrinsic ...

"We differentiate induced pluripotent stem cells into cardiac muscle cells, fibroblasts and endothelial cells. Then we mix them with mesenchymal stem cells in a certain ratio and pipette the cell ...