Cachexia, a condition affecting a significant number of advanced cancer patients, leads to severe weight loss, muscle wasting, and reduced quality of life, often limiting the ability to tolerate ...

"Future drugs targeting these neurons could help make cancer cachexia a treatable disease," the researchers suggested. In healthy patients, 'IL-6' plays a vital role in natural immune response.

A dysfunction in muscle blood vessels could be to blame for the weak muscles and weight loss that most cancer patients experience, according to a new study from University of Illinois Chicago ...

The patients in the trial had elevated levels of GDF-15, a primary driver of cachexia. Ponsegromab is a type of drug known as a monoclonal antibody, and in this trial, it improved many aspects of ...

For the first time, researchers have identified a protein that represses the activity of energy-burning brown fat. The ...

Researchers discovered a drug that safely and effectively helped cancer patients when they suffered from cachexia (ku-KEK-see-uh), a common condition related to cancer that involves weight loss ...

Ponsegromab increased weight and activity levels in cachexia patients, confirming GDF-15 as a key driver and therapeutic target. Significant weight gain was observed in ponsegromab-treated groups ...

Researchers at WashU Medicine identified a direct connection between cancer-related inflammation and the loss of motivation characteristic of advanced cancer. In a mouse study, they describe a ...

New research published in Science suggests apathy and lack of motivation are symptoms of a condition called cancer cachexia. Cold Spring Harbor Laboratory (CSHL) Associate Professor Tobias Janowitz ...

This matches what patients describe: “Everything feels too hard.” Perhaps most exciting, we found several ways to restore motivation in mice suffering from cancer cachexia − even when the ...

Preclinical and clinical data demonstrate that neutralizing GDF-15 with visugromab effectively alleviates cancer-induced cachexia, characterized by severe weight and muscle mass loss Patients with ...