Panelists discuss how the data from the BRAVE-AA1 and BRAVE-AA2 phase 3 trials demonstrated the safety and efficacy of baricitinib, leading to its FDA approval in 2022 as the first systemic treatment ...

Cytokines are proteins ... by preventing dysfunction and enhancing cytotoxicity of tumour-specific CD8 + T cells. TILT-123 is an oncolytic adenovirus encoding TNFα and IL-2.

Panelists discuss how switching therapies in patients with alopecia areata (AA) is often necessary when initial treatments fail, though it can create a cost burden, and how beyond updated guidelines, ...

Study: GZMK-expressing CD8+ T cells promote recurrent airway inflammatory ... promote inflammation and tissue damage by releasing cytokines and cationic proteins. The pro-inflammatory role of ...

Interleukins are cytokines produced and secreted mainly ... dysfunction and enhancing cytotoxicity of tumour-specific CD8 + T cells. TILT-123 is an oncolytic adenovirus encoding TNFα and IL ...

Findings indicate that altering glucose metabolism in T cells boosts their therapeutic potential against melanoma, paving the way for improved immunotherapies.

The cytotoxic CD8+ and γδ+ T cell response in the epithelium is thought to be predominantly cytokine-driven and T cell receptor (TCR)-independent, however recent work has challenged this. We ...

Stationed within the meninges, squads of immune cells lie in wait, ready to unleash an inflammatory assault within the brain if needed. Holding these trigger-happy troops back during peacetime falls ...

the presence of conventional CD4+ and CD8+ T cells in the human enthesis including PEB and spinal soft tissue. In health, these exhibited regulatory features including high TGFβ1 transcripts, but low ...

The LNP-mRNA modality is a novel approach that uses lipid nanoparticles to deliver messenger RNA into cells. The mRNA acts as ...

Mayo Clinic researchers have identified a targeted therapy that could bring relief to people living with lichen planus, a ...

CD8 T cells were isolated from spleens of mice ... For analysis of intracellular cytokines, cells were cultured with phorbol 12-myristate 13-acetate (Sigma, P8139, 50 ng/mL), ionomycin (Sigma, I9657, ...