eLife3d
Multi-Omics Single-Cell Analysis Reveals Key Regulators of HIV-1 Persistence and Aberrant Host Immune Responses in Early Infection
This study provides evidence that single-cell multi-omics profiling can reveal key regulators of HIV-1 persistence and early immune dysregulation, particularly implicating KLF2 and Th17 cells as major ...
Medscape17d
How High should the CD4 Cells Go?
Among the most common: What is a "good" T-cell response to effective therapy? How high "should" the CD4-cell count rise in order to minimize AIDS-related morbidity and mortality? To find answers ...
NHS England8d
NHS expands HIV opt-out testing to 30 more A&Es
Thousands more people across England are to benefit from routine HIV testing in A&Es this year, thanks to the extension of a major NHS public health initiative. Under a new expansion plan, 30 more ...
Frontiers15d
Antigen presentation by clonally diverse CXCR5+ B cells to CD4 and CD8 T cells is associated with durable response to immune checkpoint inhibitors
Introduction: Increased T cell ... to count per million (cpm) expression value using the R package edgeR (v3.32.1, RRID : SCR_012802). Batch effect was corrected using removeBatchEffect function in ...
Frontiers10d
Non-linear association between CD4+ T-cell counts and mortality risk in people living with HIV: evidence from a 10-year cohort study
Background: The study aimed to investigate the dose–response association between CD4+ T-cell counts and mortality risk in people living with HIV (PLHIV). Methods: Data on PLHIV who had a high ...
Nature20d
Update on the laboratory diagnosis and monitoring of HIV infection
In China, a popular screening test is a particle agglutination ... Opti-CIM (CIMA), Zymmune (Zynaxis), TRAxCD4 (T Cell Dxs, and Innogenetics), CD4 Count Chip (SemBio), the Capcellia (Sanofi ...
Nature26d
Flow cytometry smaller and better
In addition to stability, the researchers test the response to different ... as it provides a quick and accurate way to count CD4 + and CD8 + T cells in HIV-infected patients.
Daily Mail5d
How 'normal' blood test results can still mean you have a serious illness... but there is a way you can spot the hidden warning signs
For example, a white blood cell count that ... if you get a blood test that is classed as abnormal because it is outside the range of 95 per cent of the population, don’t panic – it may ...
BMJ20d
Cancer in HIV-positive and HIV-negative adolescents and young adults in South Africa: a cross-sectional study
We assumed a CD4 cell count test indicates being HIV positive but CD4 testing maybe performed for other reasons. Since this was a population of only AYAs diagnosed with cancer, the ORs could be ...
verywellhealth9d
What Is Lymphopenia?
An overall low white blood cell count (leukopenia) is most often detected when your healthcare provider orders a test for a condition you're already ... Lymphopenia is when your blood doesn't have ...
verywellhealth6d
HIV Symptoms at Each Stage
HIV symptoms vary by the stage of infection, known as acute HIV infection (Stage 1), chronic HIV infection (Stage 2), and AIDS (Stage 3). During primary infection, the symptoms are caused by the virus ...
Cystic Fibrosis Foundation22d
About Cystic Fibrosis
When the protein is not working correctly, it’s unable to help move chloride — a component of salt — to the cell surface. Without the chloride ... for the most common CF mutations. Therefore, the test ...