eLife3d
Multi-Omics Single-Cell Analysis Reveals Key Regulators of HIV-1 Persistence and Aberrant Host Immune Responses in Early Infection
This study provides evidence that single-cell multi-omics profiling can reveal key regulators of HIV-1 persistence and early immune dysregulation, particularly implicating KLF2 and Th17 cells as major ...
Medscape15d
Low CD4-Cell Counts - Not Just About OI Risk
In a cohort of patients receiving ART, lower CD4-cell counts increased the risk not only for AIDS-defining conditions but also for non-AIDS-defining disease. Lower CD4-cell counts among HIV ...
Medscape17d
How High should the CD4 Cells Go?
How high "should" the CD4-cell count rise in order to minimize AIDS-related morbidity and mortality? To find answers, researchers analyzed clinical data from 16 cohort studies including more than ...
Yahoo17d
Red tide raging in Gulf as cell counts hit 20 million cells per liter off Sanibel
Red tide cell counts are well into the "death zone" in Lee County waters as toxins in the Gulf have turned normally turquoise waters copper. The Florida Department of Health in Lee County issued ...
The New England Journal of Medicine18d
CD4+ T-Cell Lymphoma Harboring a Chimeric Antigen Receptor Integration in TP53
Immunohistochemical analysis showed a dense lymphocytic infiltration of the lamina propria positive for T-cell receptor (TCR) α, CD3, CD4 ... Molecular Pathology Laboratory at MSKCC.
BMJ19d
Normal human enthesis harbours conventional CD4+ and CD8+ T cells with regulatory features and inducible IL-17A and TNF expression
1 University of Leeds Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds, UK Background The human enthesis conventional T cells are poorly characterised. Objectives To study the biology ...
Nature20d
Update on the laboratory diagnosis and monitoring of HIV infection
The diagnosis of HIV infection is most commonly accomplished using tests to detect antibody ... Zymmune (Zynaxis), TRAxCD4 (T Cell Dxs, and Innogenetics), CD4 Count Chip (SemBio), the Capcellia ...
Frontiers20d
CD4/CD8 ratio and CD8+ T-cell count as prognostic markers for non-AIDS mortality in people living with HIV. A systematic review and meta-analysis
Background: In people living with HIV (PLHIV), the CD4/CD8 ratio has been proposed as a useful marker for non-AIDS events. However, its predictive ability on mortality over CD4 counts, and the role of ...
Frontiers20d
Empowering adolescents living with perinatally-acquired HIV: tailored CD4+ count assessment for optimized care, the EDCTP READY-study
CD4 cell count was conducted using the Pima CD4 (Abbott/Pantech (Pty) Ltd., Westville, South Africa) automatic test, following the manufacturer’s instructions (17). The Pima test consists of a ...
BMJ20d
Analysis of the immunological response to antiviral therapy in patients with different subtypes of HIV/AIDS: a retrospective cohort study
Complete laboratory blood tests before receiving ART; (2) Living in Huzhou area including temporary residents; (3) Starting ART between 1 January 2018 and 31 December 2020; (4) Having a complete ...
healthday25d
Long COVID Severity Linked to White Blood Cell Count
WEDNESDAY, Jan. 29, 2025 (HealthDay News) -- A simple blood test might determine which patients are at ... and to verify the link between white blood cell counts and long COVID risk, researchers said.