It directly interacts with the complement system, which is key to innate immunity. In coronavirus disease 2019 (COVID-19), dysregulation of the hemostatic and complement systems has been associated ...
Modulation of complement AP and CP biomarkers by PPY988 delivery. Fold-changes (y-axis) in complement biomarker [FI, C3, FH, FB, C1q, Ba, C3a, C3b/iC3b, C4b, Ba:FB, C3a:C3, C3b/iC3b:C3] concentrations ...
The structure of complement protein C3 reveals a large, modular protein consisting of 13 domains with a buried thioester moiety. Proteolytic activation of C3 into C3b induces conformational ...
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