My research interests are in the area of synthetic medicinal chemistry. We design and synthesize molecules using state of the art techniques. We focus on multi-disciplinary collaborative projects to ...

For all complement-activating antibodies, C3b deposition on the surface of K. pneumoniae caused activation of complement-mediated phagocytosis and elimination by human neutrophils. Antibody ...

Modulation of complement AP and CP biomarkers by PPY988 delivery. Fold-changes (y-axis) in complement biomarker [FI, C3, FH, FB, C1q, Ba, C3a, C3b/iC3b, C4b, Ba:FB, C3a:C3, C3b/iC3b:C3] concentrations ...

This correlated with a marked post-treatment reduction in VH concentration of the FB breakdown product Ba and Ba:FB ratio, but minimal changes in C3a and C3b/iC3b levels. Variable concordance in ...

Complement activation may promote atherosclerosis. Yet, data on the to which extent complement, and more specifically the alternative complement pathway, is activated in patients with carotid ...

These nanostructures demonstrated a favorable safety profile, as evidenced by the absence of significant cell cytotoxicity, coagulation activation, complement system activation, and the slight ...

Results: Complement Factor D(CFD) gene is identified as the highly expressed hub gene and is positively correlated with IL-2. IL-2 is also positively correlated with CD27 on CD24+CD27+B cells, ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. While pancreatic beta-cell proliferation has ...

Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109, USA Dr J P Lynch III, Department of Internal Medicine, Division of Pulmonary and Critical ...