A collaborative team from Penn Medicine and Penn Engineering has uncovered the mathematical principles behind a ...

C3b promotes opsonization through binding and activation of components C1q and C3b, and reinforces complement activation. C3a activates glial cells, particularly microglia (green).

The N-terminal site [complement control protein (CCP) domains 1-6] bound C3b with a Kd of 0.08 μM and this interaction was not influenced by the presence or absence of domains 7 and 8. Full length ...

A collaborative team from the School of Engineering and Applied Science and the Perelman School of Medicine have unraveled ...

Key Takeaways Dysregulated complement pathways are linked to progression from iAMD to advanced AMD, including NVAMD and GA. Higher systemic levels of C4, C4b, and a reduction in C3 are associated ...

"The complement system is perhaps the oldest-known part of our extracellular immune system," says Jacob Brenner, a physician-scientist at the University of Pennsylvania. "It plays a crucial role ...

TSP-1 directly bound alternative complement pathway proteins, including factor H, factor B, C3, C5, and C8. Surface plasmon resonance analysis revealed high-affinity interactions with C5 (47 nM ...

The Chairman of the Niger Delta Development Commission Governing Board, Mr. Chiedu Ebie, has said that the commission is not a tier of government but that it work is to complement what other tiers ...