A collaborative team from Penn Medicine and Penn Engineering has uncovered the mathematical principles behind a ...

C3b promotes opsonization through binding and activation of components C1q and C3b, and reinforces complement activation. C3a activates glial cells, particularly microglia (green).

Human complement C3b inactivator: isolation, characterization, and demonstration of an absolute requirement for the serum protein beta1H for cleavage of C3b and C4b in solution. J Exp Med. (1977) ...

A collaborative team from the School of Engineering and Applied Science and the Perelman School of Medicine have unraveled ...

Key Takeaways. Dysregulated complement pathways are linked to progression from iAMD to advanced AMD, including NVAMD and GA. Higher systemic levels of C4, C4b, and a reduction in C3 are associated ...

The complement system, a key component of the immune response, operates based on a critical percolation threshold determined by the density of complement-binding sites on foreign surfaces.

Konwar S, Schroda S, Rogg M, et al. Thrombospondin-1 inhibits alternative complement pathway activation in antineutrophil cytoplasmic antibody-associated vasculitis. J Clin Invest.Published online ...

The Chairman of the Niger Delta Development Commission Governing Board, Mr. Chiedu Ebie, has said that the commission is not a tier of government but that it work is to complement what other tiers ...