Three papers in this issue report the first X-ray structures of C3b, the active form of human complement C3. The complement system is a family of blood serum proteins and cell-surface receptors ...

The complement receptor 1 (CR1) gene encodes a transmembrane glycoprotein that functions in the innate immune system. CR1 is expressed on blood cells and microglia. As a receptor for the complement ...

A collaborative team from Penn Medicine and Penn Engineering has uncovered the mathematical principles behind a ...

A collaborative team from the School of Engineering and Applied Science and the Perelman School of Medicine have unraveled the mathematics of a 500-million-year-old protein network that acts like the ...

Complement component 3, often called C3, is an essential protein of the immune system. This protein plays a vital role in the body’s innate immune system, providing: the first line of defense ...

The researchers used neurodegeneration mouse models to test the effects of boosting Nptx2 levels or blocking complement protein in cells. In one of these mice models, a lack of Nptx2 was tied to ...

Lakers linked to $97 million center to complement Luka Doncic. Story by Matthew Wadleigh • 1d. T he Los Angeles Lakers lost in the first round with the superstar duo of LeBron James and Luka Doncic.

NM3086 blocked the deposition of C3b via AP, a marker of extravascul Phase I Clinical Trial in healthy subjects shows that NM3086 was safe and well tolerated at all doses (0.1 to 20 mg/kg) in six ...

Inhibitors of proximal and terminal complement cascades can often control red-cell hemolysis associated with paroxysmal nocturnal hemoglobinuria, but some patients have breakthrough hemolysis.

C3b is a recognizable ligand for circulating macrophages, which bind to the subunit through the CR1 receptor and engulf the entity. The other subunit resulting from C3 cleavage is C3a, an ...