NovelMed announce positive 12-week interim results from phase II trial of Ruxoprubart in adult patients with PNH: Cleveland Wednesday, May 21, 2025, 12:00 Hrs [IST] NovelMed, a cl ...

CLEVELAND, May 19, 2025 (GLOBE NEWSWIRE) -- NovelMed is pleased to announce positive 12-week interim results from the ongoing multi-dose Phase II trial of Ruxoprubart, a novel complement-targeting ...

The cleavage products C2a and C4b then form a C3 convertase, which initiates the complement cascade by cleaving the C3 protein. The complex of mannose-binding lectin and its proteases functions ...

Ruxoprubart works by binding to Bb and selectively inhibiting the protease activity of the Alternative Pathway C3 convertase, while preserving the Classical Pathway. By acting proximally in the ...

This inhibition prevents the formation of C3 convertase, a critical enzyme in the complement cascade, thereby limiting the cleavage of C3 and the downstream generation of other complement components ...

Central to all 3 pathways of complement activation (classical, lectin, and alternative) is the enzyme C3 convertase that cleaves C3 to generate C3a with covalent binding of C3b fragment to the invader ...

Ruxoprubart works by binding to Bb and selectively inhibiting the protease activity of the Alternative Pathway C3 convertase, while preserving the Classical Pathway. By acting proximally in the ...

As is common with CNG-powered vehicles, the power and torque figures for the Citroen C3 CNG are expected to be slightly reduced compared to its petrol counterparts. It claims an ARAI-certified ...

The Citroen C3 is offered with two engine options - a 1.2-litre three-cylinder naturally aspirated unit that produces 82hp and 115Nm and comes paired with a 5-speed manual. The other engine is the ...

Citroen India has announced its entry into the CNG vehicle market with the C3 hatchback. The car will be available with a retrofitted CNG kit across the brand's dealerships via a certified ...

C3.ai, Inc. AI and UiPath Inc. PATH are both high-profile players in the booming AI automation sector. C3.ai specializes in enterprise AI applications, including predictive maintenance and ...