This study identifies 53BP1 as an interaction partner of GMCL1 (a likely CUL3 substrate receptor). The study seeks to link this finding to regulation of the mitotic surveillance pathway and paclitaxel ...

Heuermann is expected back in court Friday as his lawyers ask a judge to disqualify some of the DNA evidence pertaining to nuclear DNA results obtained from hairs recovered from six victims ...

FAM171A2 clamps onto α-synuclein’s C-terminus. Curiously, an approved cancer drug blocks this interaction, barring α-synuclein’s entry. New variants in the FAM171A2 gene associated with Parkinson’s.

While six years ago they found that these so-called SMC motor proteins make long loops in our DNA, they have now discovered that these motors also put significant twists into the loops that they form.

In this project, we investigated the roles of the N-terminus, C-terminus, and CRD within a recombinant protein ... specific domains while keeping the histidine tag upstream of the DNA construct. The ...

To assemble these minuscule structures, researchers first create a scaffold: a long piece of single-stranded DNA with a carefully ... symbol and heated it to 95 °C for a few minutes to separate ...

Finally, we show that co-depletion of ORC1 and CDC6 by the double-degron system completely suppresses DNA replication ... We fused mAID-BromoTag to the N-terminus of endogenous ORC1(mAB-ORC1). The mAB ...

The Lightning port, which arrived on the iPhone 5 in 2012, has finally been replaced by the non-proprietary USB-C standard, which means it’s compatible with a wider range of cables, chargers ...

The detailed survey of the mammoth genome was made possible after an international team of scientists figured out how to adapt a technique dubbed Hi-C to examine ancient DNA (SN: 8/24/15).

The YENPTY motif at APP’s C-terminus routes it to the endosome ... They crossed these to mice expressing Cas9 in the brain, the endonuclease that carries out CRISPR’s DNA snipping. To target APP’s ...

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