Here, we expand the repertoire of PROTAC compatible E3 ligases by identifying a novel small molecule scaffold targeting the ubiquitin E3 ligase KLHDC2 using a fluorescence polarization-based high ...

The following steps were applied: (1) parsing CIF files into molecular format, (2 ... There are plenty of techniques for substituent or ligand features that are geometry based. (47) The most common ...

The United Nations Framework Convention on Climate Change (UNFCCC) is an international treaty established in 1992 to cooperatively address climate change issues. The ultimate objective of the UNFCCC ...

anthropogenic (human-caused) emissions by sources and removals by sinks annual emissions estimates dating back to 1990 Note that to account for the creation of Nunavut in 1999, data for years ...

More information: Francesca Chandler et al, Molecular glues that inhibit deubiquitylase activity and inflammatory signaling, Nature Structural & Molecular Biology (2025). DOI: 10.1038/s41594-025 ...

If successful, they could revolutionize how we interface with and control biology at the molecular level. Credit: SciTechDaily.com DNA strand displacement circuits are inching closer to becoming ...

This study aims to conduct a comprehensive analysis of recent advancements in research on protein modifications in hepatic ischemia-reperfusion injury, investigate the underlying molecular mechanisms, ...

State Key Laboratory of Vaccines for Infectious Diseases, Center for Molecular Imaging and Translational Medicine, Xiang’An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen ...

The Department of Cell and Molecular Biology at Karolinska Institutet is a nationally leading academic research center of high international standard where science comes first and foremost. CMB ...