Acute myelogenous leukemia, or AML, remains one of the most aggressive blood cancers. Each year, around 44,000 people in the ...

In the study, "Single-cell Transcriptional Atlas of Human Hematopoiesis Reveals Genetic and Hierarchy-Based Determinants of Aberrant AML Differentiation," published in Blood Cancer Discovery ...

This process, known as differentiation, must be precisely regulated to ensure a balanced production of mature blood cells across all cell types. An international team of scientists from ...

In blood stem cell differentiation, single-cell transcriptomics and imaging-based studies have demonstrated that key TFs are expressed in smooth, overlapping gradients throughout the stem and ...

The research team systematically profiled metabolic changes through each red blood cell maturation stage. “We found that glutamine metabolism is completely reversed during later differentiation, ...

Blood stem cells develop through different stages to become fully mature red blood cells. This fundamental biologic process ...

Researchers have developed a method to confidently produce blood cell precursors from stem ... the mechanisms driving stem cells differentiation are so fundamental that are shared between species.

Unlike targeting many other HbF repressors, upregulation of PGC-1 alpha does not affect red blood cell differentiation, suggesting that modulating PGC-1 alpha activity would be a novel and safer ...

While each cell contains the complete genetic ... This impairs the formation of blood cells by disrupting the differentiation of hematopoietic stem cells, inducing excessive production of myeloid ...

An Autolus Therapeutics cell therapy has won FDA approval for treating an aggressive blood cancer ... Phipps said Aucatzyl’s differentiation on safety and REMS reporting warrants a premium ...

Immune thrombocytopenia (ITP) is characterized by an isolated low platelet count while maintaining normal white blood cell count and hemoglobin levels. This autoimmune disorder involves peripheral ...