This useful manuscript describes cryo-EM structures of archaeal proteasomes that reveal insights into how occupancy of binding pockets on the 20S protease regulates proteasome gating. The evidence ...

Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to ...

Endogenous intracellular allosteric modulators of GPCRs remain largely unexplored, with limited binding and phenotype data available. This gap arises from the lack of robust computational methods for ...

Abstract: Temporal graph learning aims to generate high-quality representations for graph-based tasks with dynamic information, which has recently garnered increasing attention. In contrast to static ...

Master data science in 2025. Complete guide to machine learning, big data analytics, Python programming, statistical modeling ...

A man who allegedly stole children's underwear and peered into bathrooms has been charged with 28 sexual and property offences. Carla Mascarenhas is the NSW correspondent covering breaking news ...

bDivision of Reproductive Health, Warwick Medical School, University of Warwick, Coventry, UK cWarwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK dWarwick ...

When it comes to picking a smartwatch, it’s sensible to look for something that not only provides you with reliable, accurate data but helps build healthy habits as well. That’s why the Huawei ...

So, assuming that the S&P 500 had a standard deviation of 18% over a 10-year period, a return of 10%, and the risk-free rate of 5%, we can determine the Sharpe ratios for the following portfolio ...

What to Read Next Here are the best low calorie alcohol drinks to sip at home or order at a bar, according to nutritionists ... and sugars low. The standard recipe includes a large double ...

The son of a Maroons legend and twin brother of a current Broncos star has been charged by police following an alleged off-field attack on a rival Queensland Cup player. Sport Confidential can ...

Rome Free Academy girls golf defended its crown with a stellar showing at the Tri-Valley League Championships on Wednesday at the Skenandoa Club. The Black Knights (9-0) breezed past the ...