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The Fantastic Four: First Steps has officially kicked off Phase 6, bringing Marvel's first family into the MCU and in their own universe (Earth-828), separate from the 'main' MCU universe (Earth-616).
If you don't want to get bogged down with side content, here are 10 games that are better if you mainline the story.
Long story, short: Tom Holland's Spider-Man currently exists in the MCU, with the other Sony Spider-Man movies existing (broadly speaking) in the multiverse and aren't a concern for this watch order.