Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly ...

Autophagy, derived from a Greek word, the "self-eating" nature refers to an interesting cellular process as part of the body's own recycling mechanism for cellular damage or components that have ...

Researchers have identified how autophagy and chaperone-mediated autophagy (CMA) drive the unconventional secretion of PARK7, ...

An international research team led by Osaka University has identified a new mechanism crucial for the initiation of autophagy, a self-degradation process cells use to eliminate unneeded or damaged ...

Table 2 Association of Autophagy-Related Factors and Human Disease. Autophagy primarily acts as a protective mechanism that may prevent cell death. Interaction between regulatory elements of both ...

The ULK1 complex is known to translocate from the cytoplasm to the endoplasmic reticulum membrane, where autophagosomes are formed at the onset of autophagy. However, the underlying mechanism and ...

Autophagy is a natural, self-preservation mechanism whereby the body removes damaged or dysfunctional parts of a cell and recycles other parts toward cellular repair. Autophagy is the body’s way ...

BIRMINGHAM, Alabama -- When stuff wears out inside of the cells in your body, a mechanism akin to trash collection kicks into gear. It’s called autophagy (pronounced aw-TAH-fa-gee). In a ...

In many cases the root of resistance to BRAF inhibitors may lie in a never-before-seen autophagy mechanism induced by the BRAF inhibitors vermurafenib and dabrafenib, new research indicates.

These sequential reactions trigger efficient autophagy induction. Osaka, Japan – An international research team led by Osaka University has identified a new mechanism crucial for the initiation ...