Rett syndrome is a rare genetic disease affecting 1 in 10,000 newborn girls, characterized by sudden regression around 1 year ...

stabilizer TH-301 in models of pancreatic ductal adenocarcinoma (PDAC). It was seen that treatment with TH-301 led to significant dose-, time- and cell type-dependent decreases in viability.

“Interferon regulatory factor-1 signaling regulates the switch between autophagy and apoptosis to determine ... that IRF1 was downregulated in antiestrogen-resistant breast cancer cell lines, ...

Cells break down and recycle their components in a process called autophagy. Researchers now suggest that autophagy may play a role in thwarting cancer. They used healthy human cells and turned off ...

A recent study from Tata Institute of Fundamental Research, Mumbai, India has revealed new details about how our cells clean up and recycle waste. This process, known as autophagy, is like a self ...

Autophagy defects have been linked to aging, as well as, with the emergence of age-related disorders, such as diabetes, ...

Arginine deprivation also gives rise to a host of conditions within cancer cells, including increased autophagy ... who have failed at least two lines of prior systemic treatments.