Nature9d
Self-eating and self-killing: crosstalk between autophagy and apoptosis
Several proteins that have an essential role in autophagy have a direct or indirect impact on the regulation or execution of apoptosis. As an example, Atg5 is an essential autophagy inducer ...
Hosted on MSN29d
Powering brain health: How autophagy protects neurons by controlling their glucose consumption
More information: Janine Tutas et al, Autophagy regulator ATG5 preserves cerebellar function by safeguarding its glycolytic activity, Nature Metabolism (2025). DOI: 10.1038/s42255-024-01196-4 ...
Frontiers11d
Rice stripe virus p2 protein interacts with ATG5 and is targeted for degradation by autophagy
Autophagy can be induced by viral infection and plays antiviral roles in plants, but the underlying mechanism is not well understood. In our previous reports, we have demonstrated that the plant ATG5 ...
Frontiers10d
The interplay between autophagy and cGAS-STING signaling and its implications for cancer
Autophagy is an intracellular process that targets various ... to produce phosphatidylinositol 4-phosphate (PI4P) that recruits ATG12-ATG5-ATG16L1. The ATG16L1 complex then induces the formation of ER ...
PNAS29d
Ufmylation reconciles salt stress-induced unfolded protein responses via ER-phagy in Arabidopsis
Prolonged ER stress responses are detected in ufl1 mutants that phenocopy the autophagy dysfunction atg5 mutants. Consistently, expression of ufmylation cascade components is up-regulated by salt ...
eLife14d
Endosomal-lysosomal organellar assembly (ELYSA) structures coordinate lysosomal degradation systems through mammalian oocyte-to-embryo transition
After fertilization, the embryo degrades parts of the maternal components via lysosomal degradation systems, including autophagy and endocytosis, as zygotic gene expression begins during embryogenesis ...
gut.bmj9d
Inhibition of monoacylglycerol lipase, an anti-inflammatory and antifibrogenic strategy in the liver
In vivo and in vitro, anti-inflammatory and antifibrogenic effects of MAGL inhibitors are mediated by autophagy in macrophages. In the present study, we investigated whether MAGL may constitute a ...
eLife16d
ATG6 interacting with NPR1 increases Arabidopsis thaliana resistance to Pst DC3000/ avrRps4 by increasing its nuclear accumulation and stability
This important study investigates the role of ATG6 in regulating NPR1, a key protein in the plant immune response. The authors present compelling evidence that ATG6 not only interacts with NPR1 in ...
thorax.bmj10d
Viral and host factors determine innate immune responses in airway epithelial cells from children with wheeze and atopy
Background Airway epithelial cells (AEC) from patients with asthma, appear to have an impaired interferon (IFN)-β and -λ response to infection with rhinovirus. Objectives To determine if impaired IFN ...
C&EN16d
Hyaluronic Acid-Coated SPIONs with Attached Folic Acid as Potential T2 MRI Contrasts for Anticancer Therapies
Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Kraków, Poland Doctoral School of Exact and Natural Sciences, Jagiellonian University, Prof. S. Łojasiewicza 11, 30-348 Kraków, ...