Neuropathological analysis of such lesions revealed apoptotic neurons and inflammatory cells as well as neurons with transected axons surrounded by activated microglia. Chronic inflammation indeed ...

the research team treated α-synucleinopathy neurons with varying doses of PD98059 or SP600125, selective inhibitors against ERK1/2 and JNK, respectively, and examined for apoptotic activation.

In the brain, it accumulates in dying neurons following seizures and hypoxic ... (a model of cerebral palsy), there was evidence of apoptotic changes (neuronal caspase-3 activation), as well ...