Finally, we demonstrate that caspase 3 is activated and that ... the Ras-induced inhibition of apoptosis under differentiation-inducing conditions is MEK independent. To investigate further ...

Caspase-3 activity has been described to be essential for drug-induced apoptosis. Recent results suggest that in addition to its downstream executor function, caspase-3 is also involved in the ...

In turn, caspase 9 activates caspase 3. Smac/Diablo binds ... further caspase activation. Apoptosis-inducing factor and endonuclease G mediate caspase-independent cell-death pathways.

Scientists commonly use caspase assays to evaluate apoptosis, evaluating caspase activation—a hallmark of apoptosis initiation—with fluorescent dyes. Researchers often perform multiplex caspase assays ...