69–72 Possession of ApoE ε4 and ageing impact adversely on all these molecular and cellular clearance mechanisms, as well as on ATP-binding cassette transporters involved in the clearance of Aβ.73–75 ...

Macrophages play a central role in the development of atherosclerotic cardiovascular disease (ASCVD), which encompasses coronary artery disease, peripheral artery disease, cerebrovascular disease, and ...

Explore the functional characterization of 3D neurospheres in healthy and Alzheimer’s models using iPSC-derived neurons.

Introduction: There are three isoforms of apolipoprotein E (apoE) in humans (e2/e3/e4). They differ by single amino acid substitutions, which variably affect their affinity for the LDL receptor.

A new study, published today in Nature Communications, offers clues into how APOE isoforms differentially affect human microglia function in Alzheimer's disease. The study, led by Dr Sarah Marzi and ...

Many companies are concerned that investments will be in jeopardy amid House Republicans’ passage of a tax bill that would gut clean energy credits, non-partisan group E2 said in its analysis of ...

Participants wore activity trackers on their wrists, received MRI scans, and were tested for the APOE-e4 gene, which indicates Alzheimer's disease risk. More sitting time was associated with worse ...

We further tested for the effects of a history of hysterectomy ± bilateral oophorectomy among MHT users and examined associations by APOE ε4 status. Current MHT users, not past users, showed older ...

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In the early phase of Alzheimer’s disease, astrocytes are the primary source of APOE in the brain. This study examined the effects of astrocyte-derived human APOE isoforms in APOE-deficient mouse ...

V. Rossi) Muscle repair after injury entails an immune response that orchestrates efficacious regeneration. Here we identify Prostaglandin E2 (PGE2) as a crucial inflammatory mediator of muscle stem ...