The APOE gene—coding for a protein involved in lipid transport and implicated in the clearance of amyloid-beta, one of the proteins that builds up in the brain in Alzheimer’s disease—exists ...

There are three common forms of APOE – e2, e3 and e4, all distinct alleles that have varying risks of Alzheimer's Disease (AD).

ApoE is the major cholesterol-carrying protein in the brain. It has been studied since its discovery as an AD risk gene in the early 1990s, but is newly emerging as a hub for glial responses to ...

Anna M. Bennet, Ph.D., of the University of Cambridge, England, and colleagues conducted a review of studies to reassess associations of apoE genotypes with circulating lipid levels and coronary ...

More information: Elizabeth E. Blue et al, Local ancestry at APOE modifies Alzheimer's disease risk in Caribbean Hispanics, Alzheimer's & Dementia (2019). DOI: 10.1016/j.jalz.2019.07.016 Provided ...

APOE E2/E2 Is Associated with Slower Rate of Cognitive Decline with Age. Journal of Alzheimer's Disease, 2021; 83 (2): 853 DOI: 10.3233/JAD-201205 ...

A gene called apolipoprotein E (APOE), long implicated in Alzheimer's disease, has two variants that act differently among Caribbean Hispanics depending on the ancestral origin, according to a ...

HP encodes the antioxidant blood protein haptoglobin, which binds to ApoE. HP comes in two variants, and one, HP2, tempers AD risk in APOE4/E2 carriers but heightens risk in people who are E4/E4, the ...

Variants in the ApoE gene are the strongest genetic risk factor there is for developing Alzheimer’s disease. Inheriting the E2 allele decreases the number of plaques, while inheriting the E4 allele ...