The APOE gene—coding for a protein involved in lipid transport and implicated in the clearance of amyloid-beta, one of the proteins that builds up in the brain in Alzheimer’s disease—exists ...

Variants in the ApoE gene are the strongest genetic risk factor there is for developing Alzheimer’s disease. Inheriting the E2 allele decreases the number of plaques, while inheriting the E4 allele ...