6 13 Genetic deficiency in apoE and also the presence of apoɛ2 and apoɛ4 genes in the population are associated with predisposition to atherosclerosis and Alzheimer's disease, respectively.

ApoE-knockout mice-which develop spontaneous hypercholesterolemia and atherosclerosis after about four months and neurodegeneration after eight months-crossed with aP2-knockout mice had up to 87 ...

The APOE gene encodes apolipoprotein E ... People who inherit APOE4 have an elevated risk of atherosclerosis due to high levels of circulating cholesterol. In contrast, those who inherit APOE2 ...

Atherosclerosis is the buildup of fats ... The apolipoprotein E-null (ApoE −/−) mice model is an extremely popular murine representative of human lesions. Studies using this in vivo system ...

The most widely used model of atherosclerosis is a mouse lacking the protein “apolipoprotein E”, or ApoE. Using mice without ApoE that they engineered to also lack Favine, the team observed ...

Atherosclerosis, a disease characterized by the accumulation of lipids and inflammatory cells in the arterial wall, is a significant cause of cardiovascular events. A key process in atherosclerosis is ...

Thus, the role of taurine in atherosclerosis remains controversial ... and lowered the ratio of anti-α-SMA to anti-CD68 staining in ApoE −/− mice. Additionally, taurine treatment increased ...

Researchers have demonstrated the specific role microRNA plays in atherosclerosis -- and how it manages to intervene in this signaling pathway. Atherosclerosis is considered a frequent cause of ...

The APOE gene encodes apolipoprotein E ... People who inherit APOE4 have an elevated risk of atherosclerosis due to high levels of circulating cholesterol. In contrast, those who inherit APOE2 ...