We have reported that deletion of activating FcγRs in apolipoprotein E (apoE) single knockout mice attenuated atherosclerosis. In this report, we investigated the hypothesis that deficiency of ...

Atherosclerosis models are usually limited to vertebrates ... To mention some specific examples, conditional deletion of Apoe in adult mice caused a transition to hypercholesterolemia that was ...

Atherosclerosis (AS) is a chronic inflammatory disease characterized ... (85) reported that dapagliflozin treatment ameliorated aortic AS formation in streptozotocin-induced diabetic ApoE−/− mice. The ...

*placebo adjusted mITT analysis; # MACE = composite of death, resuscitated cardiac arrest, acute myocardial infarction (STEMI and NSTEMI), hospitalization for unstable angina, stroke and coronary ...

Furthermore, those who carried the APOE-e4 allele, a genetic risk factor for Alzheimer’s disease, were even more likely to face those outcomes. open image in gallery Previous research has tied ...

today announced additional data from the BROADWAY and TANDEM pivotal Phase 3 studies were presented as late-breaking oral presentations at the European Atherosclerosis Society Congress (“EAS ...

All the things that define AD pathogenesis—the seeding and growth of Aβ plaques, withering of surrounding synapses, propagation of tau tangles, and infiltration of circulating immune cells into the ...

The company’s Repatha (evolocumab) was added to optimised statin therapy in a phase 3 trial, and resulted in statistically significant regression of atherosclerosis in patients with coronary ...

Novo Nordisk has announced plans to move its ziltivekimab into phase 3 clinical development in atherosclerosis with chronic kidney disease after a mid-stage trial met its main goal. The Danish ...

In the early phase of Alzheimer’s disease, astrocytes are the primary source of APOE in the brain. This study examined the effects of astrocyte-derived human APOE isoforms in APOE-deficient mouse ...