The company’s Repatha (evolocumab) was added to optimised statin therapy in a phase 3 trial, and resulted in statistically significant regression of atherosclerosis in patients with coronary ...

APOE is the strongest risk gene for late onset Alzheimer’s disease and its expression is upregulated in microglia in response to amyloid beta. Here, the authors show that the APOE isoforms show ...

Novo Nordisk has announced plans to move its ziltivekimab into phase 3 clinical development in atherosclerosis with chronic kidney disease after a mid-stage trial met its main goal. The Danish ...

During atherosclerosis, lipid-rich plaques are formed in large- and medium-sized arteries, which can reduce blood flow to tissues. This situation becomes particularly precarious when a plaque develops ...

Methods Two cardiac MRI cohorts were included: 2106 participants (median age: 65 years, 54% women) from the Multi-Ethnic Study of Atherosclerosis (MESA) and 2960 participants (median age: 64 years, 52 ...

Cardiomegaly describes the enlargement of the heart, and mild cardiomegaly generally refers to a slight enlargement that causes no symptoms. There are many different causes of mild cardiomegaly, ...