The secondary structure annotation was generated in the template of HSV-1 gB. Identical residues are shown as white symbols on red background, and similar residues are shown as red symbols.

Cholera can be a deadly problem for children in third world countries. Epidemic outbreaks in the past have involved changes to the pilin protein, now structurally characterized by Scripps researchers.

Using chitinase, a protein known to be secreted by V. cholerae by the same mechanism as cholera toxin, the researchers engineered a series of insertions, deletions and mutations in its amino-acid ...