About Rezdiffra Rezdiffra is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. It is the first approved medication for the treatment of MASH in the U.S ...

Women with a history of preeclampsia have a nearly 2-fold increased risk of myocardial infarction later in life. The women with (n=82,980) and without (n=1,883,116) a history of preeclampsia had mean ...

Background: Endogenous hydrogen sulfide (H2S) and its key generating enzyme, cystathionine β-synthase (CBS), prevent vascular remodeling and damage to target organs during the advancement of ...

The paddleboard crossing is part of the 10th annual crossing for cystic fibrosis, raising funds for Piper’s Angels, a nonprofit supporting families affected by the disease.

PHILADELPHIA — Hypercortisolism is tied to multiple cardio-renal-metabolic disorders, making cortisol level screening an important part of patient monitoring, according to speakers at the Heart ...

This site contains general information about cystic fibrosis, as well as personal insight from the CF community. Opinions and experiences shared by members of our community, including but not limited ...

Myocardial inflammation (24% vs 0%; OR, 38.6; 95% CI, 2.2-671.7; P =.01) and small-vessel coronary vasculopathy (18% vs 0%; OR, 27.4; 95% CI, 1.6-485.0; P =.02) were observed exclusively in the SSc ...

Liver fibrosis is characterised by the excessive deposition of extracellular matrix (ECM) in response to chronic and sustained liver damage, triggering a prolonged wound healing response. The ...

Objective Extracellular matrix protein 1 (ECM1) serves as a gatekeeper of hepatic fibrosis by maintaining transforming growth factor-β1 (TGF-β1) in its latent form. ECM1 knockout (KO) causes latent (L ...

Salt sensitivity is a well-recognized contributor to cardiovascular risk, traditionally linked to elevated blood pressure. However, emerging evidence suggests that high dietary sodium may also promote ...

Nanoparticles that undergo a localized morphology change to target areas of inflammation have been previously developed but are limited by their lack of biodegradability. In this paper, we describe a ...

HealthDay News — For patients with metabolic dysfunction-associated steatohepatitis (MASH), treatment with dapagliflozin is beneficial for improvement of MASH without worsening of fibrosis and for ...