Alzinova AB (ALZ) announces new clinical results showing that healthy elderly people naturally have high levels of protective antibodies against toxic amyloid-ß oligomers, which are reduced in Alzheim ...

Roche and Prothena are advancing Prasinezumab to Phase 3 for Parkinson’s despite mixed Phase 2 results. Click here to read an ...

For the first time, scientists say, they have evidence that using a biologic drug to remove sticky beta amyloid plaques from the brains of people destined to develop Alzheimer’s dementia can ...

According to the amyloid hypothesis, amyloid brain burden ... and quantified by densitometry in (G). A42 beta‐sheet‐rich assembly formation monitored by increase in ThT fluorescence over time with BSA ...

Piller is an investigative journalist for Science. In November 2022, Dennis Selkoe, a Harvard professor of neurologic diseases and among the most celebrated and prolific Alzheimer’s researchers ...

The future of SMITE is growing up fast. SMITE 2 is officially leaving its alpha behind and taking its first major step forward by launching its beta. SMITE 2 received a massive update and will now ...

The protein amyloid beta, which occurs naturally in the brain ... knocked out BACE1 in the neurons and oligodendrocytes of mice. They then used 3D light-sheet microscopy to study plaque formation ...

Sun and colleagues were able to make measurements of amyloid fibril beta-sheet assemblies, the underlying girders of the protein conglomeration, while they were changing. Previous high-resolution ...

Beta-amyloid plaques are considered a hallmark of Alzheimer’s disease, but they’re not the sole cause of the disease and its symptoms. Alzheimer’s is a complicated disease that experts are ...

Inactivation of prions and amyloid seeds with hypochlorous acid ... Parallel in-register intermolecular beta sheet architectures for prion seeded PrP amyloids. J Biol Chem. 2014 Aug ...

This important study uses a novel light sheet imaging technique to investigate how different ... signals via the Myddosome when triggered by lipopolysaccharide (LPS) or amyloid-beta (Aβ) aggregates ...

These tau peptide fibrils propagate aggregated intracellular tau over multiple generations, have a high β-sheet content ... suggest a similar rationale might be applied to the amyloid-beta-peptide (69 ...