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The alternative pathway is activated by the cell surfaces of foreign pathogens and spontaneous hydrolysis of C3. Initiation of the classical pathway leads to cleavage of complement factor C3 into ...

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The third is the alternative pathway, which is an amplifier of those two pathways. When complement gets activated, it releases anaphylatoxins C3a and C5a that are potent chemotactic agents.

"We look forward to discussing the data with regulators so we can bring this first-in-class alternative complement pathway inhibitor as the first oral monotherapy to people living with PNH," he added.