Frontiers12d
Energy metabolism and the intestinal barrier: implications for understanding and managing intestinal diseases
Disruptions in energy metabolism can compromise the integrity of the intestinal barrier; for example, inactivation of the AMPK pathway may lead to reduced expression of proteins associated with tight ...
Frontiers17d
Nicotinamide Riboside and Metformin Ameliorate Mitophagy Defect in Induced Pluripotent Stem Cell-Derived Astrocytes With POLG Mutations
Taken together, these data indicate that POLG mutations induced astrocytic mitophagy failure by regulating the AKT/mTOR/AMPK/ULK1 signaling pathway. Nicotinamide Riboside and Metformin Treatment ...
eLife20d
Novel Mechanism for Tubular Injury in Nephropathic Cystinosis
This important study addresses the idea that defective lysosomal clearance might be causal to renal dysfunction in cystinosis. With mostly solid data, the authors observe that restoring expression of ...
eLife20d
Novel Mechanism for Tubular Injury in Nephropathic Cystinosis
Division of Multi-Organ Transplantation, Department of Surgery, University of California, San Francisco, San Francisco, United States Bakar Computational Health Sciences Institute, University of ...
C&EN22d
Small Molecule Modulators of AMP-Activated Protein Kinase (AMPK) Activity and Their Potential in Cancer Therapy
Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, Colorado 80045, ...
C&EN27d
The P2X7-Mediated Mitochondrial ROS as an Emerging Core Target of Tuftsin Nanoparticles in Severe Acute Pancreatitis Therapy via Regulating Mitophagy
Department of Critical Care Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, People’s Republic of China ...