Shenzhen Zhongge Biotechnology Co. Ltd. has divulged AMP-activated protein kinase α1β1γ1 activators reported to be useful for the treatment of acute kidney injury, alopecia, chronic kidney disease, ...

Protein Kinase A (PKA): An enzyme that becomes activated upon binding to cAMP and phosphorylates target proteins, thereby modulating numerous cellular functions.

Background: AMP-activated protein kinase (AMPK) can phosphorylate BRAF and block its activation of MEK. AMPK is activated by biguanides such as metformin and phenformin (phen). Preclinical data ...

BRAF is among the most commonly mutated genes in human cancer. 1 BRAF is most frequently mutated at codon V600, resulting in enhanced activation of the downstream mitogen-activated protein kinase ...