The adult mammalian heart bears limited regenerative capacity, resulting in the irreversible loss of cardiomyocytes post-cardiac injury, and often culminating in end-stage heart failure. Cardiomyocyte ...

Key cardiac transcription factors require precise regulation for heart development and function. Here, the authors show that the miR-200 family controls cardiomyocyte differentiation and maturation, ...

“The additional data from MAPLE-HCM expands our understanding of aficamten across several measures of exercise performance, with effects observed not only in peak exercise capacity, but also in ...

Background: Theoretically, 3D multi-cellular cardiac spheroids (3D-MCS) composed of CMs, ECs, and CFs could mimic important features of the human heart microenvironment. We developed injectable ...

THE detection of a continuous murmur with systolic accentuation is of the highest significance in the diagnosis and in the location of the site of an arteriovenous fistula. It is therefore appropriate ...

Abstract: Objective: Non-invasive focused ultrasound therapies of abdominal organs, including the heart and the liver, have emerged in the last decades. Transthoracic focusing of ultrasound poses ...

Chaperone proteins such as αB-Crystallin (CRYAB) are critical for maintaining protein quality in cardiomyocytes. CRYAB mutations provoke aggregation of CRYAB and its client protein, Desmin, resulting ...

Abstract: Three-dimensional (3D) cardiac magnetic resonance T2 mapping has been proven beneficial for the diagnosis of myocardial edema. However, the time-consuming nature of cardiac quantitative ...