Preclinical and observational studies suggest that exercise may improve cancer outcomes. However, definitive level 1 evidence ...

A collection of articles and other resources on the Coronavirus (Covid-19) outbreak, including clinical reports, management guidelines, and commentary.

The rapid accrual of knowledge in genomic medicine has prompted the reanalysis of existing data. 1,2 We clinically reanalyzed data from two patient series that had undergone diagnostic proband ...

The analysis population consisted of 2536 patients (1270 in the edoxaban group and 1266 in the placebo group). The mean age was 78 years, 37.4% were women, and the median duration of AHREs was 2.8 ...

Adipose tissue is an underappreciated and misunderstood organ. Capable of more than doubling in mass and then returning to baseline, 1 white adipose tissue (WAT) continues to play an essential ...

We describe two cases of acquired parathyroid hormone (PTH) resistance consequent to the development of serum PTH type 1 receptor (PTH1R) autoantibodies, which block PTH binding and signaling.

Persistent fever with an elusive cause has been recognized for more than a century. In 1907, Cabot, a cofounder of the Clinicopathological Conferences at Massachusetts General Hospital ...

The mechanisms involved in the development of cardiovascular disease in persons with type 1 diabetes are shown. Data from randomized, controlled trials examining the effect of statins on ...

Phenotypes Acute hepatic necrosis, serum enzyme elevations, sinusoidal obstruction, acute fatty liver, nodular regeneration Acute hepatocellular hepatitis, mixed or cholestatic hepatitis, bland ...

Pulmonary hypertension is a syndrome characterized by marked remodeling of the pulmonary vasculature and a progressive rise in the pulmonary vascular load, leading to hypertrophy and remodeling of ...

Hormone absence or inactivity is common in congenital disease, but hormone antagonism remains controversial. Here, we characterize two novel homozygous leptin variants that yielded antagonistic ...

In critically ill, mechanically ventilated patients, daily interruption of sedation has been shown to reduce the time on ventilation and the length of stay in the intensive care unit (ICU).