Preclinical and observational studies suggest that exercise may improve cancer outcomes. However, definitive level 1 evidence is lacking. In this phase 3, randomized trial conducted at 55 centers, ...

A collection of articles and other resources on the Coronavirus (Covid-19) outbreak, including clinical reports, management guidelines, and commentary.

Previous results from this trial showed longer overall survival after treatment with nivolumab plus ipilimumab or with nivolumab monotherapy than with ipilimumab monotherapy in patients with ...

Pulmonary hypertension is a syndrome characterized by marked remodeling of the pulmonary vasculature and a progressive rise in the pulmonary vascular load, leading to hypertrophy and remodeling of ...

Shown are the phases of rupture and healing of an atherosclerotic plaque. The cross-section of a plaque in Panel A shows a central core containing lipids and necrotic debris (yellow) and ...

We and others identified retinoblastoma features that suggested that the tumors originate in long- and medium-wavelength cone precursors, and we discovered features of these cone precursors that ...

This review article presents two true-life clinical vignettes that illustrate how digital health technology can aid providers caring for patients with epilepsy. Specific information that would ...

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when ...

A total of 187 patients underwent randomization. Of these patients, 40% had non–small-cell lung cancer, 32% had pancreatic cancer, and 29% had colorectal cancer. At 12 weeks, patients in the ...

Dr. Jacqueline B. Henson (Medicine): A 54-year-old man was evaluated at this hospital after cardiac arrest associated with ventricular fibrillation. The patient had been in his usual state of ...

Autoimmune pulmonary alveolar proteinosis (aPAP) is a disease characterized by alveolar filling that leads to progressive accumulation of surfactant in alveoli, hypoxemia, and in some patients ...