This study highlights novel genotype-driven metabolic adaptations in PM, laying the groundwork for targeted interventions ...

MicroRNA-33a and microRNA-33b are encoded within the mammalian SREBF1 and SRBF2 genes, respectively, and both SREBF1 and ...

STIM1 is an endoplasmic reticulum (ER) membrane Ca 2+ sensor responsible for activation of store‐operated Ca 2+ influx. We discovered that STIM1 oligomerization and store‐operated Ca 2+ entry (SOC) ...

Phosphatidylserine (PS) is a phospholipid mainly enriched in the inner leaflet of the plasma membrane; however, its role in the nucleus remains unclear. This study describes the presence of PS in the ...

The gut microbiome is essential for processing complex food compounds and synthesizing nutrients that the host cannot digest or produce, respectively. New model systems are needed to study how the ...

The reason why ApoE4 is a risk factor in Alzheimer's disease is unknown. This study shows that lipoproteins containing ApoE4, but not those containing ApoE3, upregulate the communication between ER ...

image image Whether metabolite‐sensing enzyme AMPK regulates cell survival upon amino acid starvation, remains unclear. This study identifies the cysteine‐specific tRNA synthetase (CARS) as an ...

Transient receptor potential vanilloid (TRPV) channels play a critical role in calcium homeostasis, pain sensation, immunological response, and cancer progression. TRPV channels are blocked by ...

In the practice of medicine, many fundamental biological pathways that require tight on/off control, such as inflammation and circulatory homeostasis, are regulated by serine proteinases, but we ...

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EMBO Press publishes five scientific journals: The EMBO Journal - Submit here The EMBO Journal has been EMBO's flagship publication for 40 years. With a scope that spans all areas of molecular biology ...

In the present work, we measured and characterized molecular and genetic recombination events occurring in response to replication inhibition in mammalian cells. Cells were treated with different ...