Ischemic stroke in younger adults is far less common than that among older adults, yet the underlying pathogeneses and risk factors are more diverse. Approximately 10% to 15% of all strokes occur in ...

Background— Smoking is a major cause of cardiovascular disease mortality. There is little information on how it contributes to global and regional cause-specific mortality from cardiovascular diseases ...

Cardiovascular events have their greatest prevalence in the early morning period. Whether this is attributable to an arousal-dependent blood pressure (BP) increase is far from being clear. It is also ...

Age-associated central arterial wall stiffness is linked to extracellular matrix remodeling, including fibrosis and vascular calcification. Angiotensin II induces both matrix metalloproteinase 2 (MMP2 ...

Cardiovascular disease (CVD) remains a major health burden despite significant therapeutic advances accomplished over the last decades. It is widely and increasingly recognized that systemic ...

The addition of either obesity or high-density lipoprotein cholesterol to the models that included systolic blood pressure (BP) and diastolic BP, total cholesterol, diabetes, and current smoking did ...

Background— The ability to derive human induced pluripotent stem (hiPS) cell lines by reprogramming of adult fibroblasts with a set of transcription factors offers unique opportunities for basic and ...

Increased renin gene expression along with hypertrophy of JGCs is found during long-term, enhanced renin release. In addition to the hypertrophy of juxtaglomerular cells, the abovementioned ...

To align with its mission to reduce the global burden of raised blood pressure (BP), the International Society of Hypertension (ISH) has developed worldwide practice guidelines for the management of ...

Resistant hypertension is defined as failure to achieve goal blood pressure (BP) <140/90 mm Hg (or <130/80 mm Hg in patients with diabetes mellitus or chronic kidney disease) in patients with ...

Letter by Forfia and Borlaug Regarding Article, “Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction: A Target of Phosphodiesterase-5 Inhibition in a 1-Year Study” ...

Along with our entire team, I have learned a great deal in the 2 years since I was tapped to be Editor-in-Chief of Circulation. Now, looking back, I have reflected on the insights we’ve gleaned during ...