Anti-HER2/neu therapy is well-established in breast and gastric carcinoma. The increased understanding of this pathway led to the identification of new promising drugs in addition to trastuzumab ...

The neu gene encodes a 185-kDa transmembrane glycoprotein, referred to as p185neu, HER2, or erbB-2, possessing intrinsic protein tyrosine kinase activity. The receptor consists of an extracellular ...

Their study, published in the online journal, Breast Cancer Research, on Nov. 29, 2004, showed that the vaccine protected 86 percent of experimental mice against HER2/neu-associated breast cancer ...

Long-term outcomes of patients with HER2-positive invasive lobular carcinoma in the ALTTO trial (BIG 2-06/NCCTG N063D [Alliance]). This is an ASCO Meeting Abstract from the 2025 ASCO Annual Meeting I.

AI-assisted training notably improved pathologist accuracy in HER2-low breast cancer, reducing misclassification and ...

TapImmune Licenses HER2/neu Antigen Technology from Mayo Clinic for Incorporation into a Vaccine to Treat HER2/neu Breast Cancer April 16, 2012, Seattle WA, TapImmune Inc. (OTCBB: TPIV ...

the VENTANA HER2/neu (4B5) IUO (investigational use only) Assay system, according to an algorithm adapted from the 2018 American Society of Clinical Oncology–College of American Pathologists ...

The FISH (fluorescence in situ hybridization) test checks the DNA of your cancer cells for extra copies of the HER2/neu gene. This gene makes proteins called HER2 (human epidermal growth factor ...

They also assess this HER2/neu protein to determine: is this one of the cases that is overexpressed and has excess protein? Or is this indeed a case where there is the standard amount of HER2/neu ...

It works against a protein called HER2 (also sometimes referred to as HER2/neu), which is short for human epidermal growth factor receptor 2. Herceptin can treat early lymph node-positive and more ...

The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated. Relationships are self-held unless noted. I = Immediate Family ...

But the biotech pushes on, licensing Mayo Clinic's HER2/neu vaccine technology to develop vaccines for any cancer where the HER2/neu gene is overexpressed. Mayo Clinic initially licensed the ...