The increasingly mainstream technique called cryo-electron microscopy, or cryo-EM, may be used to investigate the high-resolution structures of biomolecules—and discern how biomolecules interact ...

Although initially X-ray crystallography was commonly used, the much more versatile EM is now the standard approach in the form of cryo-EM, with recent advances giving us unprecedented looks at ...

IVD is a key enzyme in leucine catabolism, catalyzing the conversion of isovaleryl-CoA to 3-methylcrotonyl-CoA.

A team of biochemists devised a solution that makes it possible to hold small protein molecules in place while they're being imaged, which will enable cryo-EM to produce much clearer images of ...

The radiation emitted by high-resolution cryo-EM instruments can damage proteins. And some parts of proteins can be harmed more than others, complicating imaging. To reduce radiation damage and ...

Get Instant Summarized Text (Gist) A magnetic bead-based method, MagIC cryo-EM, reduces sample loss during cryo-EM preparation by up to 1,000-fold, enabling imaging of rare or hard-to-purify ...

Cryo-EM is rapidly becoming the method of choice for structural biologists and biochemists around the world, helping these scientists accelerate their research and expand their analytical capabilities ...

Overall structure of a transmembrane ZIP zinc transporter protein determined by cryo-electron microscopy (cryo-EM) (left) and a schematic showing some of the functional features (right).

Molecular Intelligence’s end users are research scientists in bioengineering, medical science and pharmaceutical companies who use cryo-EM to determine 3D structures of proteins, nucleic acids and ...

In a recent study published in Nature, researchers used cryo-electron microscopy (cryo-EM) to visualize the structure and dynamics of a membrane microdomain in yeast cells. They aimed to ...

Sample loss has been a persistent problem in cryo-EM, a high-tech method for creating 3D models of molecules that reveals their inner structures. It occurs during an essential step of imaging ...