On Friday, head coach Sean McDermott and the Bills officially announced via X that Oliver and Milano are declared out against the Saints. That’s two big losses, with the linebacker racking up nine tackles, one sack, one tackle for loss, one quarterback hit and one pressure through two games.

NFL Week 4 odds, picks, predictions, TV channel, streaming information for the Sunday football game between the New Orleans Saints and Buffalo Bills.

The Buffalo Bills enter Week 4 relatively healthy and as massive favorites heading into their first 1 p.m. home game of the season against the New Orleans

Buffalo Bills' second year wide receiver Keon Coleman says that the New Orleans Saints' defense presents "no challenges" in Week 4.

The Buffalo Bills will continue to be without two starters on defense as both defensive tackle Ed Oliver and linebacker Matt Milano were ruled out of Sunday's game vs. the New Orleans Saints.